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KMID : 0613820110210060838
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Journal of Life Science
2011 Volume.21 No. 6 p.838 ~ p.844
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Gender-Specific Changes of Plasma MDA, SOD, and Lymphocyte DNA Damage during High Intensity Exercise
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Cho Su-Youn
Chung Young-soo
Kwak Yi-Sub
Roh Hee-Tae
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Abstract
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The purpose of this study was to investigate gender-specific changes of plasma MDA, SOD, and lymphocyte DNA damage during high intensity exercise. In this study, 17 healthy male and 18 healthy female college students ran on a treadmill at 85%VO2max until the point of all-out. Blood-collecting was carried out five times (Rest, Ex-Exha, R0.5h, R4h and R24h), and with the collected blood, plasma malondialdehyde (MDA), superoxide dismutase (SOD), and lymphocyte DNA damage were analyzed. Plasma MDA and SOD concentration increased significantly at the Ex-Exha (p＜0.05), and there were no significant differences in gender. For the degree of lymphocyte DNA damage, all %DNA in the tail, tail length and tail moment increased significantly at the Ex-Exha (p＜0.05), and %DNA in the tail and tail length were significantly higher in the male group than in the female group (p＜0.05). These results suggest that acute high intensity exercise not only causes oxidative stress but also brings about lymphocyte DNA damage. In addition, it was found that males showed higher DNA damage than females in terms of oxidative stress subject to high intensity exercise. Nevertheless, further subsequent studies are required in order to better understand the mechanism behind DNA damage varying with gender, in a way that takes into consideration physical fitness, hormonal level, exercise intensity and duration ? additional factors which might affect DNA damage.
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KEYWORD
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High intensity exercise, malondialdehyde(MDA), superoxide dismutase(SOD), DNA damage, gender difference
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